Frontiers in Veterinary Science (Jan 2024)
China-origin G1 group isolate FPV072 exhibits higher infectivity and pathogenicity than G2 group isolate FPV027
- Qiaoqiao Xie,
- Qiaoqiao Xie,
- Qiaoqiao Xie,
- Zhen Sun,
- Zhen Sun,
- Zhen Sun,
- Xiu Xue,
- Xiu Xue,
- Xiu Xue,
- Yajie Pan,
- Yajie Pan,
- Yajie Pan,
- Shuye Zhen,
- Shuye Zhen,
- Shuye Zhen,
- Yang Liu,
- Yang Liu,
- Yang Liu,
- Jiuyu Zhan,
- Linlin Jiang,
- Linlin Jiang,
- Linlin Jiang,
- Jianlong Zhang,
- Jianlong Zhang,
- Jianlong Zhang,
- Hongwei Zhu,
- Hongwei Zhu,
- Hongwei Zhu,
- Xin Yu,
- Xin Yu,
- Xin Yu,
- Xingxiao Zhang,
- Xingxiao Zhang,
- Xingxiao Zhang
Affiliations
- Qiaoqiao Xie
- School of Life Sciences, Ludong University, Yantai, China
- Qiaoqiao Xie
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Qiaoqiao Xie
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Zhen Sun
- School of Life Sciences, Ludong University, Yantai, China
- Zhen Sun
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Zhen Sun
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Xiu Xue
- School of Life Sciences, Ludong University, Yantai, China
- Xiu Xue
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Xiu Xue
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Yajie Pan
- School of Life Sciences, Ludong University, Yantai, China
- Yajie Pan
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Yajie Pan
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Shuye Zhen
- School of Life Sciences, Ludong University, Yantai, China
- Shuye Zhen
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Shuye Zhen
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Yang Liu
- School of Life Sciences, Ludong University, Yantai, China
- Yang Liu
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Yang Liu
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Jiuyu Zhan
- School of Life Sciences, Ludong University, Yantai, China
- Linlin Jiang
- School of Life Sciences, Ludong University, Yantai, China
- Linlin Jiang
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Linlin Jiang
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Jianlong Zhang
- School of Life Sciences, Ludong University, Yantai, China
- Jianlong Zhang
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Jianlong Zhang
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Hongwei Zhu
- School of Life Sciences, Ludong University, Yantai, China
- Hongwei Zhu
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Hongwei Zhu
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Xin Yu
- School of Life Sciences, Ludong University, Yantai, China
- Xin Yu
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Xin Yu
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- Xingxiao Zhang
- School of Life Sciences, Ludong University, Yantai, China
- Xingxiao Zhang
- Collaborative Innovation Center for the Pet Infectious Diseases and Public Health in the Middle and Lower Stream Regions of the Yellow River, Yantai, China
- Xingxiao Zhang
- Provincial Engineering Research Center for Pet Animal Vaccines, Yantai, China
- DOI
- https://doi.org/10.3389/fvets.2024.1328244
- Journal volume & issue
-
Vol. 11
Abstract
IntroductionFeline parvovirus (FPV), a single-stranded DNA virus, is accountable for causing feline panleukopenia, a highly contagious and often lethal disease that primarily affects cats. The epidemiology prevalence and pathogenicity of FPV in certain regions of China, however, remains unclear. The aim of this research was to investigate the epidemiology of FPV in different regions of China in 2021 and compare its infectivity and pathogenicity.MethodsIn this research, a total of 36 FPV strains were obtained from diverse regions across China. Phylogenetic analysis was performed based on the VP2 and NS1 sequences, and two representative strains, FPV027 and FPV072, which belonged to different branches, were selected for comparative assessment of infectivity and pathogenicity.Results and discussionThe results revealed that all strains were phylogenetically classified into two groups, G1 and G2, with a higher prevalence of G1 strains in China. Both in vitro and in vivo experiments demonstrated that FPV072 (G1 group) exhibited enhanced infectivity and pathogenicity compared to FPV027 (G2 Group). The structural alignment of the VP2 protein between the two viruses revealed mutations in residues 91, 232, and 300 that may contribute to differences in infectivity and pathogenicity. The findings from these observations will contribute significantly to the overall understanding of the molecular epidemiology of FPV in China and facilitate the development of an effective FPV vaccine.
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