Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2

Buqing Ye; Benyu Liu; Liuliu Yang; Guanling Huang; Lu Hao; Pengyan Xia; Shuo Wang; Ying Du; Xiwen Qin; Pingping Zhu; Jiayi Wu; Nobuo Sakaguchi; Junyan Zhang; Zusen Fan

doi:10.1038/s41467-017-01788-7

Nature Communications (Nov 2017)

Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2

Buqing Ye,
Benyu Liu,
Liuliu Yang,
Guanling Huang,
Lu Hao,
Pengyan Xia,
Shuo Wang,
Ying Du,
Xiwen Qin,
Pingping Zhu,
Jiayi Wu,
Nobuo Sakaguchi,
Junyan Zhang,
Zusen Fan

Affiliations

Buqing Ye: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Benyu Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Liuliu Yang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Guanling Huang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Lu Hao: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Pengyan Xia: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Shuo Wang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ying Du: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiwen Qin: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Pingping Zhu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jiayi Wu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Nobuo Sakaguchi: WPI Immunology Frontier Research Center, Osaka University
Junyan Zhang: Harvard Stem Cell Institute, Harvard Medical School
Zusen Fan: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-017-01788-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Haematopoiesis and the generation of lymphoid cell subsets are controlled by delicate genetic programs enforced via epigenetic regulation. Here the authors show that Pcid2 interacts with ZNHIT1, a component of the SRCAP chromatin remodelling complex, to critically modulate the differentiation of multipotent progenitors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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