EVALUATION OF SOME ANTIOXIDANTS’ EFFECTS IN KIDNEY HISTOLOGICAL STRUCTURE OF WEANED PIGS, INTOXICATED WITH DEOXYNIVALENOL (DON)

Abstract

Deoxynivalenol is a mycotoxin produced by fungi of the Fusarium genera, which are abundant in various cereal crops and processed grains. In order to protect cell structure within the tissues studied, we tried various experimental variants by incorporating some selenium and boron sources into the combined fodder, and also in mixture with DON with different concentrations. To determine the morphophysiological changes induced by the mycotoxin DON upon kidney histological structure, and also the antioxidants’ effects, we took samples from 9 piglets belonging to three groups: group 1 (fed with fodder added with DON), group 2 (fed with fodder added with selenium) and group 3 (fed with fodder added with selenium and DON). At renal parenchyma level, DON determines a series of changes in the renal corpuscles and also in the uriniferous tubes. These changes are represented by glomerular atrophies and nephrocyte epithelial dystrophies. The epithelial dystrophic processes occur in the renal medullar, too, where numerous ectasied capillaries and hemorrhagic areas are present. In the case of groups 2 and 3 consisted of piglets fed with fodder added with selenium, respectively fodder added with DON and selenium, the renal vascular network becomes hypertrophic associated with leukocyte infiltrative processes.

Keywords

• fusarium
• deoxynivalenol
• antioxidant
• selenium
• kidney
• histology modifications
• pig