Nature Communications (Sep 2017)
Inhibition of Y1 receptor signaling improves islet transplant outcome
- Kim Loh,
- Yan-Chuan Shi,
- Stacey Walters,
- Mohammed Bensellam,
- Kailun Lee,
- Katsuya Dezaki,
- Masanori Nakata,
- Chi Kin Ip,
- Jeng Yie Chan,
- Esteban N. Gurzov,
- Helen E. Thomas,
- Michaela Waibel,
- James Cantley,
- Thomas W. Kay,
- Toshihiko Yada,
- D. Ross Laybutt,
- Shane T. Grey,
- Herbert Herzog
Affiliations
- Kim Loh
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Yan-Chuan Shi
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Stacey Walters
- Immunology Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Mohammed Bensellam
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Kailun Lee
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Katsuya Dezaki
- Department of Physiology, Jichi Medical University
- Masanori Nakata
- Department of Physiology, Jichi Medical University
- Chi Kin Ip
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Jeng Yie Chan
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Esteban N. Gurzov
- St. Vincent’s Institute of Medical Research
- Helen E. Thomas
- St. Vincent’s Institute of Medical Research
- Michaela Waibel
- St. Vincent’s Institute of Medical Research
- James Cantley
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Thomas W. Kay
- St. Vincent’s Institute of Medical Research
- Toshihiko Yada
- Department of Physiology, Jichi Medical University
- D. Ross Laybutt
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Shane T. Grey
- Immunology Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Herbert Herzog
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00624-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.
