Nature Communications (Nov 2022)
Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling
Abstract
Here the authors show that FGF signaling initiates alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains AT2 cells throughout life. FGF inhibition triggers immediate AT2 apoptosis and compensatory regeneration.