Production of growth factors in benign and malignant prostatic diseases

Abstract

Iimmunohistochemical study of localization of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 and cells proliferative activity by Ki-67 protein has been carried out in benign prostatic hyperplasia (BPH) and adenocarcinoma (AC) of different grades by the Gleason score. A moderate positive correlation between the Gleason score and cell proliferation Ki-67 index ( rs = 0,674) and a moderate negative correlation with the level of such score and expression of matrix metalloproteinase-9 ( rs = -0,660) were detected. A weak significant negative correlation exists also between the level of proliferative activity of secretory cells and the expression of MMP-9 by tumor cell ( rs = -0,369). A significant decrease of the MMP-9 and TIMP-1 levels in the AC of different gradations have been found. The invasive properties of tumor cells, which are expressed in the destruction of collagen IV of basement membrane and connective tissue stroma of the prostate, associated with an imbalance between MMP-9 and protein blocking this enzyme - TIMP-1, expression of which decreases in AC compared to BPH.

Keywords

• аденокарцинома предстательной железы
• коллаген IV