Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

Bashar Shuoker; Michael J. Pichler; Chunsheng Jin; Hiroka Sakanaka; Haiyang Wu; Ana Martínez Gascueña; Jining Liu; Tine Sofie Nielsen; Jan Holgersson; Eva Nordberg Karlsson; Nathalie Juge; Sebastian Meier; Jens Preben Morth; Niclas G. Karlsson; Maher Abou Hachem

doi:10.1038/s41467-023-37533-6

Nature Communications (Apr 2023)

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

Bashar Shuoker,
Michael J. Pichler,
Chunsheng Jin,
Hiroka Sakanaka,
Haiyang Wu,
Ana Martínez Gascueña,
Jining Liu,
Tine Sofie Nielsen,
Jan Holgersson,
Eva Nordberg Karlsson,
Nathalie Juge,
Sebastian Meier,
Jens Preben Morth,
Niclas G. Karlsson,
Maher Abou Hachem

Affiliations

Bashar Shuoker: Department of Biotechnology and Biomedicine, Technical University of Denmark
Michael J. Pichler: Department of Biotechnology and Biomedicine, Technical University of Denmark
Chunsheng Jin: Proteomics Core Facility at Sahlgrenska Academy, University of Gothenburg
Hiroka Sakanaka: Department of Biotechnology and Biomedicine, Technical University of Denmark
Haiyang Wu: Quadram Institute Bioscience
Ana Martínez Gascueña: Quadram Institute Bioscience
Jining Liu: Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Tine Sofie Nielsen: Department of Biotechnology and Biomedicine, Technical University of Denmark
Jan Holgersson: Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Eva Nordberg Karlsson: Biotechnology, Department of Chemistry, Lund University
Nathalie Juge: Quadram Institute Bioscience
Sebastian Meier: Department of Chemistry, Technical University of Denmark
Jens Preben Morth: Department of Biotechnology and Biomedicine, Technical University of Denmark
Niclas G. Karlsson: Proteomics Core Facility at Sahlgrenska Academy, University of Gothenburg
Maher Abou Hachem: Department of Biotechnology and Biomedicine, Technical University of Denmark

DOI: https://doi.org/10.1038/s41467-023-37533-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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This study offers molecular insight into the sialidase and fucosidase decapping apparatus that initiates growth on mucin and promotes nutrient sharing by the dedicated mucolytic symbiont Akkermansia muciniphila with the mucus-associated microbiota.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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