Nature Communications (Mar 2021)
Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
Abstract
Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in a manner dependent on kin-35, without reducing protein synthesis.