Nature Communications (Jun 2019)

Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases

  • Samuel J. S. Rubin,
  • Lawrence Bai,
  • Yeneneh Haileselassie,
  • Gotzone Garay,
  • Chohee Yun,
  • Laren Becker,
  • Sarah E. Streett,
  • Sidhartha R. Sinha,
  • Aida Habtezion

DOI
https://doi.org/10.1038/s41467-019-10387-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.