Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa
In Vitro
and
In Vivo

Dina A. Moustafa; Ashley W. Wu; Danniel Zamora; Seth M. Daly; Carolyn R. Sturge; Christine Pybus; Bruce L. Geller; Joanna B. Goldberg; David E. Greenberg

doi:10.1128/mBio.02411-20

mBio (Feb 2021)

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Dina A. Moustafa,
Ashley W. Wu,
Danniel Zamora,
Seth M. Daly,
Carolyn R. Sturge,
Christine Pybus,
Bruce L. Geller,
Joanna B. Goldberg,
David E. Greenberg

Affiliations

Dina A. Moustafa: ORCiD; Department of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA
Ashley W. Wu: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Danniel Zamora: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Seth M. Daly: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Carolyn R. Sturge: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Christine Pybus: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Bruce L. Geller: Department of Microbiology, Oregon State University, Corvallis, Oregon, USA
Joanna B. Goldberg: ORCiD; Department of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA
David E. Greenberg: ORCiD; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA

DOI: https://doi.org/10.1128/mBio.02411-20
Journal volume & issue: Vol. 12, no. 1

Abstract

Read online

Numerous Gram-negative bacteria are becoming increasingly resistant to multiple, if not all, classes of existing antibiotics. Multidrug-resistant Pseudomonas aeruginosa

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal