Virus-derived DNA drives mosquito vector tolerance to arboviral infection

Bertsy Goic; Kenneth A. Stapleford; Lionel Frangeul; Aurélien J. Doucet; Valérie Gausson; Hervé Blanc; Nidia Schemmel-Jofre; Gael Cristofari; Louis Lambrechts; Marco Vignuzzi; Maria-Carla Saleh

doi:10.1038/ncomms12410

Nature Communications (Sep 2016)

Virus-derived DNA drives mosquito vector tolerance to arboviral infection

Bertsy Goic,
Kenneth A. Stapleford,
Lionel Frangeul,
Aurélien J. Doucet,
Valérie Gausson,
Hervé Blanc,
Nidia Schemmel-Jofre,
Gael Cristofari,
Louis Lambrechts,
Marco Vignuzzi,
Maria-Carla Saleh

Affiliations

Bertsy Goic: Institut Pasteur, Viruses and RNA Interference Unit, Centre National de la Recherche Scientifique UMR 3569
Kenneth A. Stapleford: Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569
Lionel Frangeul: Institut Pasteur, Viruses and RNA Interference Unit, Centre National de la Recherche Scientifique UMR 3569
Aurélien J. Doucet: IRCAN, INSERM U1081, Centre National de la Recherche Scientifique UMR 7284, University of Nice—Sophia-Antipolis
Valérie Gausson: Institut Pasteur, Viruses and RNA Interference Unit, Centre National de la Recherche Scientifique UMR 3569
Hervé Blanc: Institut Pasteur, Viruses and RNA Interference Unit, Centre National de la Recherche Scientifique UMR 3569
Nidia Schemmel-Jofre: Institut Pasteur, Viruses and RNA Interference Unit, Centre National de la Recherche Scientifique UMR 3569
Gael Cristofari: IRCAN, INSERM U1081, Centre National de la Recherche Scientifique UMR 7284, University of Nice—Sophia-Antipolis
Louis Lambrechts: Institut Pasteur, Insect-Virus Interactions Group, Centre National de la Recherche Scientifique URA 3012
Marco Vignuzzi: Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569
Maria-Carla Saleh: Institut Pasteur, Viruses and RNA Interference Unit, Centre National de la Recherche Scientifique UMR 3569

DOI: https://doi.org/10.1038/ncomms12410
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of viral-derived DNA by cellular reverse transcriptases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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