Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation

Abstract

Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) on magnetic resonance spectroscopy is a rare and little-known form of hereditary leukoencephalopathy, a significant portion of which is probably obscured by the label of primary progressive multiple sclerosis. The article presents a clinical case of an adult form of LBSL and a review of the literature on this disease, discusses the particular pyramidal syndrome lesions in LBSL and multiple sclerosis, and presents the MRI criteria for LBSL. The difficulty in differential diagnosis with Krabbe disease is highlighted. Clinical observation confirms the difficulty of diagnosing LBSL and the lack of medical awareness about this disease.

Keywords

• leukoencephalopathy
• hereditary leukoencephalopathy
• lbsl
• dars2
• spastic paraplegia of the lower limbs