Childhood factors associated with suicidal ideation among South African youth: A 28-year longitudinal study of the Birth to Twenty Plus cohort

Abstract

Background Although early life factors are associated with increased suicide risk in youth, there is a dearth of research on these associations for individuals growing up in disadvantaged socioeconomic contexts, particularly in low- and middle-income countries (LMICs). We documented the association between individual, familial, and environmental factors in childhood with suicidal ideation among South African youth. Methods and findings We used data from 2,020 participants in the Birth to Twenty Plus (Bt20+) study, a South African cohort following children born in Soweto, Johannesburg from birth (1990) to age 28 years (2018). Suicidal ideation was self-reported at ages 14, 17, 22, and 28 years, and the primary outcome of interest was suicidal ideation reported at any age. We assessed individual, familial, and socioeconomic characteristics at childbirth and during infancy, adverse childhood experiences (ACEs) between ages 5 and 13 years, and externalizing and internalizing problems between 5 and 10 years. We estimated odds ratios (ORs) of suicidal ideation for individuals exposed to selected childhood factors using logistic regression. Lifetime suicidal ideation was reported by 469 (23.2%) participants, with a 1.7:1 female/male ratio. Suicidal ideation rates peaked at age 17 and decreased thereafter. Socioeconomic adversity, low birth weight, higher birth order (i.e., increase in the order of birth in the family: first, second, third, fourth, or later born child), ACEs, and childhood externalizing problems were associated with suicidal ideation, differently patterned among males and females. Socioeconomic adversity (OR 1.13, CI 1.01 to 1.27, P = 0.031) was significantly associated with suicidal ideation among males only, while birth weight (OR 1.20, CI 1.02 to 1.41, P = 0.03), ACEs (OR 1.11, CI 1.01 to 1.21, P = 0.030), and higher birth order (OR 1.15, CI 1.07 to 1.243, P Conclusions In this study from South Africa, we observed that early life social and environmental adversities as well as childhood externalizing problems are associated with increased risk of suicidal ideation during adolescence and early adulthood. In a longitudinal study, Massimiliano Orri and colleagues study associations between individual, familial, and socioeconomic factors during childhood with suicidal ideation among South African youth. Author summary Why was this study done? Identifying childhood risk factors for suicidal ideation is key to implement population-based strategies to prevent suicide starting early in life. The literature on suicide-related outcomes in low- and middle-income countries (LMICs) is limited, with only 1 prior population-based longitudinal study from Brazil. To the best of our knowledge, no longitudinal study has been conducted in LMICs on the African continent, with evidence on risk factors for suicide-related outcomes almost uniquely relying on small cross-sectional studies and lacking information on childhood predictors. What did the researchers do and find? The authors conducted secondary analysis on data from a longitudinal population-based cohort—the Birth to Twenty Plus (Bt20+) cohort—which is the largest and longest running birth cohort in sub-Saharan Africa. Among the 2,020 participants followed up from birth (1990) to age 28 years (2018), 469 (23.2%) reported suicidal ideation between ages 14 and 28 years, with a peak in prevalence at age 17 years and an overall 1.7:1 female/male ratio. Socioeconomic adversity at the time of birth was associated with suicidal ideation among males only, while low birth weight, adverse childhood experiences (ACEs), and higher birth order were associated with suicidal ideation among females only. Externalizing problems in childhood were associated with suicidal ideation among both males and females. What do these findings mean? Addressing widespread social and environmental adversities as well as childhood externalizing problems at the population level could potentially be of interest in suicide prevention efforts in South Africa and similar LMIC contexts. Considering sex differences may be important to optimize prevention efforts. Due to attrition, this study was conducted on 62% of the initial representative sample. This may influence the generalizability of the findings to the initial population.