Water Balance Estimation in Patients with Acute Poisonings due to Psychotropic Agents

Abstract

Objective: to develop a procedure for an integrated assessment of changes in body hydration, by using the polyseg-mental bioimpedance analysis (PBIA) of the body’s water sectors. Subjects and methods. The volumes of cellular and extracellular fluids in various body regions were estimated in 85 patients with acute poisonings by psychotropic agents, by employing the PBIA over time within three days and when the impact of various treatment options on them was evaluated. An ABC-01 MEDASS device with ABC043 software was applied. Results. The study ascertained that the changes in the volumes of extracellular and cellular fluids in the upper trunk, namely progressive extracellular fluid accumulation, are the most informative parameters for disease prognosis. On this basis, the authors proposed a formula to calculate the integral hydration index (IHI) and showed its informative value when used in patients with acute poisonings due to psychotropic agents during remedial measures. Conclusion. The IHI developed on the basis of estimation of abnormal cellular and extracellular fluid volumes in patients with poisonings by psychotropic agents is sensitive and striking in the evaluation of water imbalance in patients under resuscitation and allows the detected disorders to be efficiently corrected. Key words: acute poisonings, water balance, extracellular and cellular fluid, index, hydration index.