Frontiers in Bioengineering and Biotechnology (Dec 2020)
Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature
- Antonietta Rosa Silini,
- Roberta Di Pietro,
- Roberta Di Pietro,
- Ingrid Lang-Olip,
- Francesco Alviano,
- Asmita Banerjee,
- Mariangela Basile,
- Mariangela Basile,
- Veronika Borutinskaite,
- Günther Eissner,
- Alexandra Gellhaus,
- Bernd Giebel,
- Yong-Can Huang,
- Aleksandar Janev,
- Mateja Erdani Kreft,
- Nadja Kupper,
- Ana Clara Abadía-Molina,
- Ana Clara Abadía-Molina,
- Enrique G. Olivares,
- Enrique G. Olivares,
- Enrique G. Olivares,
- Assunta Pandolfi,
- Assunta Pandolfi,
- Andrea Papait,
- Andrea Papait,
- Michela Pozzobon,
- Carmen Ruiz-Ruiz,
- Carmen Ruiz-Ruiz,
- Olga Soritau,
- Sergiu Susman,
- Sergiu Susman,
- Dariusz Szukiewicz,
- Adelheid Weidinger,
- Susanne Wolbank,
- Berthold Huppertz,
- Ornella Parolini,
- Ornella Parolini
Affiliations
- Antonietta Rosa Silini
- Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy
- Roberta Di Pietro
- Department of Medicine and Ageing Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
- Roberta Di Pietro
- StemTeCh Group, G. d’Annunzio Foundation, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
- Ingrid Lang-Olip
- Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria
- Francesco Alviano
- Department of Experimental, Diagnostic and Specialty Medicine, Unit of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
- Asmita Banerjee
- Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria
- Mariangela Basile
- Department of Medicine and Ageing Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
- Mariangela Basile
- StemTeCh Group, G. d’Annunzio Foundation, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
- Veronika Borutinskaite
- Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania
- Günther Eissner
- Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
- Alexandra Gellhaus
- Department of Gynecology and Obstetrics, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- Bernd Giebel
- 0Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Yong-Can Huang
- 1Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen, China
- Aleksandar Janev
- 2Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Mateja Erdani Kreft
- 2Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Nadja Kupper
- Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria
- Ana Clara Abadía-Molina
- 3Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain
- Ana Clara Abadía-Molina
- 4Departamento de Bioquímica y Biología Molecular III e Inmunología, Universidad de Granada, Granada, Spain
- Enrique G. Olivares
- 3Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain
- Enrique G. Olivares
- 4Departamento de Bioquímica y Biología Molecular III e Inmunología, Universidad de Granada, Granada, Spain
- Enrique G. Olivares
- 5Unidad de Gestión Clínica Laboratorios, Hospital Universitario Clínico San Cecilio, Granada, Spain
- Assunta Pandolfi
- StemTeCh Group, G. d’Annunzio Foundation, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
- Assunta Pandolfi
- 6Vascular and Stem Cell Biology, Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, CAST (Center for Advanced Studies and Technology, ex CeSI-MeT), Chieti, Italy
- Andrea Papait
- Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy
- Andrea Papait
- 7Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
- Michela Pozzobon
- 8Stem Cells and Regenerative Medicine Lab, Department of Women’s and Children’s Health, University of Padova, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy
- Carmen Ruiz-Ruiz
- 3Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain
- Carmen Ruiz-Ruiz
- 4Departamento de Bioquímica y Biología Molecular III e Inmunología, Universidad de Granada, Granada, Spain
- Olga Soritau
- 9The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania
- Sergiu Susman
- 0Department of Morphological Sciences-Histology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
- Sergiu Susman
- 1Department of Pathology, IMOGEN Research Center, Cluj-Napoca, Romania
- Dariusz Szukiewicz
- 2Department of General and Experimental Pathology with Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, Warsaw, Poland
- Adelheid Weidinger
- Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria
- Susanne Wolbank
- Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria
- Berthold Huppertz
- Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria
- Ornella Parolini
- 7Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
- Ornella Parolini
- 3Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy
- DOI
- https://doi.org/10.3389/fbioe.2020.610544
- Journal volume & issue
-
Vol. 8
Abstract
Progress in the understanding of the biology of perinatal tissues has contributed to the breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth-associated tissues, cells, and secreted factors. The significant knowledge acquired in the past two decades, along with the increasing interest in perinatal derivatives, fuels an urgent need for the precise identification of PnD and the establishment of updated consensus criteria policies for their characterization. The aim of this review is not to go into detail on preclinical or clinical trials, but rather we address specific issues that are relevant for the definition/characterization of perinatal cells, starting from an understanding of the development of the human placenta, its structure, and the different cell populations that can be isolated from the different perinatal tissues. We describe where the cells are located within the placenta and their cell morphology and phenotype. We also propose nomenclature for the cell populations and derivatives discussed herein. This review is a joint effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the processing and in vitro characterization and clinical application of PnD.
Keywords
