Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

Anand Patwardhan; Sabine Bardin; Stéphanie Miserey-Lenkei; Lionel Larue; Bruno Goud; Graça Raposo; Cédric Delevoye

doi:10.1038/ncomms15835

Nature Communications (Jun 2017)

Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

Anand Patwardhan,
Sabine Bardin,
Stéphanie Miserey-Lenkei,
Lionel Larue,
Bruno Goud,
Graça Raposo,
Cédric Delevoye

Affiliations

Anand Patwardhan: Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments
Sabine Bardin: Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport
Stéphanie Miserey-Lenkei: Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport
Lionel Larue: Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes
Bruno Goud: Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport
Graça Raposo: Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments
Cédric Delevoye: Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments

DOI: https://doi.org/10.1038/ncomms15835
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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