Single-cell transcriptomics of the goldfish retina reveals genetic divergence in the asymmetrically evolved subgenomes after allotetraploidization

Tetsuo Kon; Kentaro Fukuta; Zelin Chen; Koto Kon-Nanjo; Kota Suzuki; Masakazu Ishikawa; Hikari Tanaka; Shawn M. Burgess; Hideki Noguchi; Atsushi Toyoda; Yoshihiro Omori

doi:10.1038/s42003-022-04351-3

Communications Biology (Dec 2022)

Single-cell transcriptomics of the goldfish retina reveals genetic divergence in the asymmetrically evolved subgenomes after allotetraploidization

Tetsuo Kon,
Kentaro Fukuta,
Zelin Chen,
Koto Kon-Nanjo,
Kota Suzuki,
Masakazu Ishikawa,
Hikari Tanaka,
Shawn M. Burgess,
Hideki Noguchi,
Atsushi Toyoda,
Yoshihiro Omori

Affiliations

Tetsuo Kon: Laboratory of Functional Genomics, Graduate School of Bioscience, Nagahama Institute of Bioscience and Technology
Kentaro Fukuta: Center for Genome Informatics, Joint Support-Center for Data Science Research, Research Organization of Information and Systems
Zelin Chen: Translational and Functional Genomics Branch, National Human Genome Research Institute
Koto Kon-Nanjo: Department of Neurosciences and Developmental Biology, University of Vienna
Kota Suzuki: Yatomi Station, Aichi Fisheries Research Institute
Masakazu Ishikawa: KOTAI Biotechnologies, Inc.
Hikari Tanaka: KOTAI Biotechnologies, Inc.
Shawn M. Burgess: Translational and Functional Genomics Branch, National Human Genome Research Institute
Hideki Noguchi: Center for Genome Informatics, Joint Support-Center for Data Science Research, Research Organization of Information and Systems
Atsushi Toyoda: Advanced Genomics Center, National Institute of Genetics
Yoshihiro Omori: Laboratory of Functional Genomics, Graduate School of Bioscience, Nagahama Institute of Bioscience and Technology

DOI: https://doi.org/10.1038/s42003-022-04351-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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An integrated scRNA-seq and scATAC-seq analysis of retina from the goldfish, Carassius auratus, reveals global biases in expression patterns between the two (L and S) subgenomes that resulted from ancestral whole-genome duplication.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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