The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer

Roberta Roncarati; Roberta Roncarati; Laura Lupini; Ram C. Shankaraiah; Massimo Negrini

doi:10.3389/fonc.2019.00988

Frontiers in Oncology (Sep 2019)

The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer

Roberta Roncarati,
Roberta Roncarati,
Laura Lupini,
Ram C. Shankaraiah,
Massimo Negrini

Affiliations

Roberta Roncarati: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Roberta Roncarati: CNR, Institute of Genetics and Biomedical Research, National Research Council of Italy, Milan, Italy
Laura Lupini: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Ram C. Shankaraiah: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Massimo Negrini: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy

DOI: https://doi.org/10.3389/fonc.2019.00988
Journal volume & issue: Vol. 9

Abstract

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microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (HRAS, KRAS, or NRAS) activation irrespective of their oncogenic mutations. These findings revealed relevant pathogenic mechanisms as well as mechanisms of resistance to target therapies. Based on this knowledge, potential approaches for the control of RAS oncogenic activation can be envisioned.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

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