Descriptive study of clinical profile and benefit of therapy in childhood hypercalciuria

Abstract

Mahalingam Vijayakumar, Prahlad Nageswaran, O Manimegalai Tirukalathi, Ekambaram Sudha, Shweta Priyadarshini Department of Pediatric Nephrology and Pediatrics, Mehta Children's Hospital, Chennai, Tamilnadu, India Abstract: Clinical, biochemical, and ultrasonographic findings in 91 consecutive children presenting with hypercalciuria were analyzed along with the results of treatment to determine the clinical profile of hypercalciuria and its outcome. Hypercalciuria was common in children aged 1–5 years (39.6%), and hematuria was the most frequent symptom. There was no significant difference between 24-hour urinary calcium and random urinary calcium/creatinine ratio values between males and females. The random urinary calcium/creatinine ratio was found to be useful for screening and also for documenting the benefit of therapy. The children were essentially treated with thiazides, and the majority showed a good response, with a good overall outcome on follow-up. Keywords: hematuria, hypercalciuria, thiazides