Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Jun Wang; Yong-Xi Song; Bin Ma; Jia-Jun Wang; Jing-Xu Sun; Xiao-Wan Chen; Jun-Hua Zhao; Yu-Chong Yang; Zhen-Ning Wang

doi:10.3390/ijms160819886

International Journal of Molecular Sciences (Aug 2015)

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Jun Wang,
Yong-Xi Song,
Bin Ma,
Jia-Jun Wang,
Jing-Xu Sun,
Xiao-Wan Chen,
Jun-Hua Zhao,
Yu-Chong Yang,
Zhen-Ning Wang

Affiliations

Jun Wang: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Yong-Xi Song: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Bin Ma: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Jia-Jun Wang: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Jing-Xu Sun: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Xiao-Wan Chen: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Jun-Hua Zhao: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Yu-Chong Yang: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
Zhen-Ning Wang: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China

DOI: https://doi.org/10.3390/ijms160819886
Journal volume & issue: Vol. 16, no. 8
pp. 19886 – 19919

Abstract

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Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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