20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

Sorin Tunaru; Remy Bonnavion; Isabell Brandenburger; Jens Preussner; Dominique Thomas; Klaus Scholich; Stefan Offermanns

doi:10.1038/s41467-017-02539-4

Nature Communications (Jan 2018)

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

Sorin Tunaru,
Remy Bonnavion,
Isabell Brandenburger,
Jens Preussner,
Dominique Thomas,
Klaus Scholich,
Stefan Offermanns

Affiliations

Sorin Tunaru: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Remy Bonnavion: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Isabell Brandenburger: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Jens Preussner: ECCPS Bioinformatics Facility, Max Planck Institute for Heart and Lung Research
Dominique Thomas: Institut für Klinische Pharmakologie, Pharmazentrum Frankfurt, ZAFES, Klinikum der Goethe-Universität Frankfurt
Klaus Scholich: Institut für Klinische Pharmakologie, Pharmazentrum Frankfurt, ZAFES, Klinikum der Goethe-Universität Frankfurt
Stefan Offermanns: Max Planck Institute for Heart and Lung Research, Department of Pharmacology

DOI: https://doi.org/10.1038/s41467-017-02539-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion via FFAR1 activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal