Frontiers in Medicine (Apr 2024)

Does adjunctive hemoadsorption provide benefit in the management of ischemia–reperfusion syndrome following near-drowning? A case report

  • Pedja Kovacevic,
  • Pedja Kovacevic,
  • Sasa Dragic,
  • Sasa Dragic,
  • Milka Jandric,
  • Danica Momcicevic,
  • Danica Momcicevic,
  • Vedrana Malesevic,
  • Tijana Kovacevic,
  • Tijana Kovacevic,
  • Marijana Matejic-Spasic,
  • Tanja Knezevic,
  • Biljana Zlojutro,
  • Biljana Zlojutro

DOI
https://doi.org/10.3389/fmed.2024.1341156
Journal volume & issue
Vol. 11

Abstract

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Drowning remains a significant global health concern, claiming over 300,000 lives annually, with a disproportionate impact on young individuals in low-and middle-income countries. Conventional mechanical ventilation, while common, falls short in addressing the hypoxemia and hypercapnia often observed in severe near-drowning cases. Veno-venous extracorporeal membrane oxygenation (vvECMO) emerges as a critical intervention for cardiopulmonary failure post-drowning. This case report delves into the pivotal role of ischemia–reperfusion injury (IRI) in a near-drowning-related pathology. Following the initial insult, reoxygenation exacerbates the inflammatory cascade, resulting in a surge of pro-inflammatory mediators. In this context, CytoSorb®, a hemoadsorption cartridge, demonstrates promise by effectively removing these mediators from circulation. This report outlines its application in a critically ill adolescent patient who experienced near-drowning, presenting a compelling case for CytoSorb as an adjunctive therapy in managing IRI-induced hyperinflammation.

Keywords