Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

Dirk A. Lamprecht; Peter M. Finin; Md. Aejazur Rahman; Bridgette M. Cumming; Shannon L. Russell; Surendranadha R. Jonnala; John H. Adamson; Adrie J. C. Steyn

doi:10.1038/ncomms12393

Nature Communications (Aug 2016)

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

Dirk A. Lamprecht,
Peter M. Finin,
Md. Aejazur Rahman,
Bridgette M. Cumming,
Shannon L. Russell,
Surendranadha R. Jonnala,
John H. Adamson,
Adrie J. C. Steyn

Affiliations

Dirk A. Lamprecht: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)
Peter M. Finin: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)
Md. Aejazur Rahman: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)
Bridgette M. Cumming: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)
Shannon L. Russell: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)
Surendranadha R. Jonnala: Tuberculosis Research Section, NIAID, NIH
John H. Adamson: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)
Adrie J. C. Steyn: KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH)

DOI: https://doi.org/10.1038/ncomms12393
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Several inhibitors of the electron transport chain (ETC) are active against Mycobacterium tuberculosis. Here, Lamprecht et al. show that a combination of known inhibitors (bedaquiline, Q203 and clofazimine) displays synergistic effects on the M. tuberculosis ETC and improved antibacterial activity in vitro.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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