RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Aleksandra Lezaja; Andreas Panagopoulos; Yanlin Wen; Edison Carvalho; Ralph Imhof; Matthias Altmeyer

doi:10.1038/s41467-021-23806-5

Nature Communications (Jun 2021)

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Aleksandra Lezaja,
Andreas Panagopoulos,
Yanlin Wen,
Edison Carvalho,
Ralph Imhof,
Matthias Altmeyer

Affiliations

Aleksandra Lezaja: Department of Molecular Mechanisms of Disease, University of Zurich
Andreas Panagopoulos: Department of Molecular Mechanisms of Disease, University of Zurich
Yanlin Wen: Department of Molecular Mechanisms of Disease, University of Zurich
Edison Carvalho: Department of Molecular Mechanisms of Disease, University of Zurich
Ralph Imhof: Department of Molecular Mechanisms of Disease, University of Zurich
Matthias Altmeyer: Department of Molecular Mechanisms of Disease, University of Zurich

DOI: https://doi.org/10.1038/s41467-021-23806-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell cycle, to allow for post-mitotic DNA synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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