Molecules (Oct 2024)

Palladium-Catalyzed C-H Functionalization and Flame-Retardant Properties of Isophosphinolines

  • Karen-Pacelye Mengue Me Ndong,
  • Mina Hariri,
  • Gabin Mwande-Maguene,
  • Jacques Lebibi,
  • Fatemeh Darvish,
  • Christine Safi,
  • Kouceila Abdelli,
  • Adam Daïch,
  • Claire Negrell,
  • Rodolphe Sonnier,
  • Loic Dumazert,
  • Abdou Rachid Issaka Ibrahim,
  • Ilagouma Amadou Tidjani,
  • David Virieux,
  • Tahar Ayad,
  • Jean-Luc Pirat

DOI
https://doi.org/10.3390/molecules29215104
Journal volume & issue
Vol. 29, no. 21
p. 5104

Abstract

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C-H activation is a powerful strategy for forming C-C bonds without the need for prefunctionalization. In this paper, we present a general, direct, and regioselective palladium-catalyzed functionalization of a phosphorus heterocycle, 2-phenyl-1H-isophosphinoline 2-oxide. The mild reaction conditions enabled the introduction of various functionalized alkenes. Moreover, the flame-retardant properties of selected products clearly highlighted the synergy between the phosphine oxide and another heteroatom-based group, even in the condensed phase.

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