Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium

Sanja Vickovic; Denis Schapiro; Konstantin Carlberg; Britta Lötstedt; Ludvig Larsson; Franziska Hildebrandt; Marina Korotkova; Aase H. Hensvold; Anca I. Catrina; Peter K. Sorger; Vivianne Malmström; Aviv Regev; Patrik L. Ståhl

doi:10.1038/s42003-022-03050-3

Communications Biology (Feb 2022)

Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium

Sanja Vickovic,
Denis Schapiro,
Konstantin Carlberg,
Britta Lötstedt,
Ludvig Larsson,
Franziska Hildebrandt,
Marina Korotkova,
Aase H. Hensvold,
Anca I. Catrina,
Peter K. Sorger,
Vivianne Malmström,
Aviv Regev,
Patrik L. Ståhl

Affiliations

Sanja Vickovic: Klarman Cell Observatory, Broad Institute of MIT and Harvard
Denis Schapiro: Klarman Cell Observatory, Broad Institute of MIT and Harvard
Konstantin Carlberg: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Britta Lötstedt: Klarman Cell Observatory, Broad Institute of MIT and Harvard
Ludvig Larsson: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Franziska Hildebrandt: Department of Molecular Biosciences, the Wenner Gren Institute, Stockholm University
Marina Korotkova: Karolinska Institutet, Division of Rheumatology, Department of Medicine, Center for Molecular Medicine
Aase H. Hensvold: Karolinska Institutet, Division of Rheumatology, Department of Medicine, Center for Molecular Medicine
Anca I. Catrina: Karolinska Institutet, Division of Rheumatology, Department of Medicine, Center for Molecular Medicine
Peter K. Sorger: Laboratory of Systems Pharmacology, Harvard Medical School
Vivianne Malmström: Karolinska Institutet, Division of Rheumatology, Department of Medicine, Center for Molecular Medicine
Aviv Regev: Klarman Cell Observatory, Broad Institute of MIT and Harvard
Patrik L. Ståhl: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology

DOI: https://doi.org/10.1038/s42003-022-03050-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

Sanja Vickovic et al. use spatial transcriptomics to probe the local synovial tissue interactions in rheumatoid arthritis (RA) patients. Their results provide a valuable resource to understand the spatial organisation of cell populations in the synovium in the context of RA-associated inflammation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal