Nature Communications (May 2019)

A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

  • Yanxian Feng,
  • Ruoyu Mu,
  • Zhenzhen Wang,
  • Panfei Xing,
  • Junfeng Zhang,
  • Lei Dong,
  • Chunming Wang

DOI
https://doi.org/10.1038/s41467-019-10354-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.