Selective Oxidation of Benzo[<i>d</i>]isothiazol-3(2<i>H</i>)-Ones Enabled by Selectfluor

Abstract

A metal-free and Selectfluor-mediated selective oxidation reaction of benzo[d]isothiazol-3(2H)-ones in aqueous media is presented. This novel strategy provides a facile, green, and efficient approach to access important benzo[d]isothiazol-3(2H)-one-1-oxides with excellent yields and high tolerance to various functional groups. Furthermore, the purification of benzoisothiazol-3-one-1-oxides does not rely on column chromatography. Moreover, the preparation of saccharine derivatives has been achieved through sequential, double oxidation reactions in a one-pot aqueous media.

Keywords

• Selectfluor
• oxidation
• benzoisothiazol-3-one-1-oxide