Biomedicines (Jan 2020)

2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis

  • Soo Young Choi,
  • Min-Jeong Heo,
  • Chanmi Lee,
  • Yeong Min Choi,
  • In-sook An,
  • Seunghee Bae,
  • Sungkwan An,
  • Jin Hyuk Jung

DOI
https://doi.org/10.3390/biomedicines8020020
Journal volume & issue
Vol. 8, no. 2
p. 20

Abstract

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Glucose metabolism is a key metabolic pathway that orchestrates cellular homeostasis by generating ATP, nucleotides, and amino acids. Abnormal glucose signaling has been found in many diseases including cancers and inflammatory diseases. According to recent report, glycolysis contributes to pathogenesis of psoriasis and ablation of Glut1 attenuates animal models of psoriasis. While we were screening a molecular target for atopic dermatitis, we found the levels of glucose transporters including Glut1 (SLC2a1) and Glut3 (SLC2a3) are highly expressed in skin biopsies of dermatitis patients from multiple datasets. We demonstrated that administration of 2-deoxy-d-glucose (2DG) ameliorates animal models of 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone induced dermatitis using morphological and histological analysis. These results suggest that inhibition of glucose metabolism ameliorates dermatitis in animal models.

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