Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children

Pei-Wei Wang; Yu-Fang Huang; Chung-Hao Wang; Li-Jung Fang; Mei-Lien Chen

Pediatrics and Neonatology (Jan 2024)

Prenatal to preschool exposure of nonylphenol and bisphenol A exposure and neurodevelopment in young children

Pei-Wei Wang,
Yu-Fang Huang,
Chung-Hao Wang,
Li-Jung Fang,
Mei-Lien Chen

Affiliations

Pei-Wei Wang: Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan
Yu-Fang Huang: Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei, Taiwan; Corresponding author. Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan.
Chung-Hao Wang: Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan
Li-Jung Fang: Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan
Mei-Lien Chen: Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei, Taiwan; Corresponding author. Institute of Environmental and Occupational Health Sciences, School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan.

Journal volume & issue: Vol. 65, no. 1
pp. 76 – 84

Abstract

Read online

Background: Nonylphenol (NP) and bisphenol A (BPA) are produced in large quantities worldwide as multipurpose agents. However, studies on relations between NP and BPA exposure and childhood neurodevelopment are few, and the results are inconsistent. This study aimed to investigate associations between prenatal and early childhood NP and BPA exposure and neurodevelopment in mother–child pairs. Methods: Pregnant women at 27–38 weeks' gestation were recruited, as were children 2–3 years of age (n = 94) and 4–6 years of age (n = 56) years. Urine was collected to assess NP and BPA exposure. Bayley Scales of Infant and Toddler Development (3rd edition; Bayley-III), Wechsler Preschool and Primary Scale of Intelligence (4th edition), and the Full Scale Intelligence Quotient (WPPSI-IV-FSIQ) were used to assess the neurodevelopment of the children. Results: The detection rate and concentration of NP and BPA in the urine of children 4–6 years old were higher than in those 2–3 years old. Children were divided into a high concentration group (3rd tertile) and a reference group (1st and 2nd tertiles) based on natural log-transformed urine concentration of NP and BPA. Girls' Bayley-III motor scores in the high concentration group were higher than those of the BPA reference group of urine of mothers (β = 6.85, 95% confidence interval [CI]: 1.58–12.13). Boys' FSIQ in the higher concentration group were significantly lower than those in children 2–3 years old in the NP reference group (β = −11.29, 95% CI: −18.62 to −3.96) (all, p < 0.05). Conclusions: Prenatal and childhood exposure to NP and BPA may have different effects on the neurodevelopment of young children, and there are no consistent effects between boys and girls.

Published in Pediatrics and Neonatology

ISSN: 1875-9572 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pediatrics
Website: https://www.journals.elsevier.com/pediatrics-and-neonatology/

About the journal

Abstract

Keywords