Marine Drugs (Mar 2018)

New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

  • Liuming Qiu,
  • Pei Wang,
  • Ge Liao,
  • Yanbo Zeng,
  • Caihong Cai,
  • Fandong Kong,
  • Zhikai Guo,
  • Peter Proksch,
  • Haofu Dai,
  • Wenli Mei

DOI
https://doi.org/10.3390/md16040108
Journal volume & issue
Vol. 16, no. 4
p. 108

Abstract

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Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.

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