Nature Communications (Mar 2022)

Landscape of adenosine-to-inosine RNA recoding across human tissues

  • Orshay Gabay,
  • Yoav Shoshan,
  • Eli Kopel,
  • Udi Ben-Zvi,
  • Tomer D. Mann,
  • Noam Bressler,
  • Roni Cohen‐Fultheim,
  • Amos A. Schaffer,
  • Shalom Hillel Roth,
  • Ziv Tzur,
  • Erez Y. Levanon,
  • Eli Eisenberg

DOI
https://doi.org/10.1038/s41467-022-28841-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Gabay et al. provide a highly-accurate atlas of recoding by A-to-I RNA editing in human, profiled across tissues and cell subpopulations. Most highly edited sites are evolutionary conserved in non-primate mammals, attesting for adaptation.