Propolis does not significantly modulate immune function in an older population: A preliminary study

Abstract

Purpose: The human trial aimed to study the influence of propolis on immune function in the elderly. Methods: Non-institutionalized community-dwelling individuals aged 60–80 years were recruited from Tianjin, China. Participants were assigned randomly to either the Chinese propolis group (600 mg/day, n = 32) or the control group (n = 30). Serum antibodies and biochemical indices were measured using commercial kits; cytokines were detected using ELISA assay, and the functions of lymphocytes and neutrophils were assayed using the MTT and Staphylococcal methods, respectively. A dietary survey was conducted based on 24-h recall. Results: The study lasted for 12 weeks. Immunoglobulin G (IgG) levels notably increased at week 6 although these levels returned to baseline by week 12 in the Chinese propolis group. No significant difference was detected in serum antibodies, cytokines, or lymphocyte and neutrophil functions between the two groups at any time point. Conclusions: Chinese propolis could stimulate IgG secretion within a certain period, but it was restored to baseline levels over time. Propolis does not significantly affect other immune markers in the elderly.

Keywords

• Propolis
• Antibody
• Cytokine
• Lymphocyte