Nature Communications (Nov 2023)
Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation
- Hu Li,
- Huarui Gong,
- Tsz Hung Wong,
- Jingkun Zhou,
- Yuqiong Wang,
- Long Lin,
- Ying Dou,
- Huiling Jia,
- Xingcan Huang,
- Zhan Gao,
- Rui Shi,
- Ya Huang,
- Zhenlin Chen,
- Wooyoung PARK,
- Ji Yu Li,
- Hongwei Chu,
- Shengxin Jia,
- Han Wu,
- Mengge Wu,
- Yiming Liu,
- Dengfeng Li,
- Jian Li,
- Guoqiang Xu,
- Tianrui Chang,
- Binbin Zhang,
- Yuyu Gao,
- Jingyou Su,
- Hao Bai,
- Jie Hu,
- Chun Ki Yiu,
- Chenjie Xu,
- Wenchuang Hu,
- Jiandong Huang,
- Lingqian Chang,
- Xinge Yu
Affiliations
- Hu Li
- Department of Biomedical Engineering, City University of Hong Kong
- Huarui Gong
- Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Tsz Hung Wong
- Department of Biomedical Engineering, City University of Hong Kong
- Jingkun Zhou
- Department of Biomedical Engineering, City University of Hong Kong
- Yuqiong Wang
- Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University
- Long Lin
- College of Engineering, Peking University
- Ying Dou
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Huiling Jia
- Department of Biomedical Engineering, City University of Hong Kong
- Xingcan Huang
- Department of Biomedical Engineering, City University of Hong Kong
- Zhan Gao
- Department of Biomedical Engineering, City University of Hong Kong
- Rui Shi
- Department of Biomedical Engineering, City University of Hong Kong
- Ya Huang
- Department of Biomedical Engineering, City University of Hong Kong
- Zhenlin Chen
- Department of Biomedical Engineering, City University of Hong Kong
- Wooyoung PARK
- Department of Biomedical Engineering, City University of Hong Kong
- Ji Yu Li
- Department of Biomedical Engineering, City University of Hong Kong
- Hongwei Chu
- Department of Biomedical Engineering, City University of Hong Kong
- Shengxin Jia
- Department of Biomedical Engineering, City University of Hong Kong
- Han Wu
- Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University
- Mengge Wu
- Department of Biomedical Engineering, City University of Hong Kong
- Yiming Liu
- Department of Biomedical Engineering, City University of Hong Kong
- Dengfeng Li
- Department of Biomedical Engineering, City University of Hong Kong
- Jian Li
- Department of Biomedical Engineering, City University of Hong Kong
- Guoqiang Xu
- Department of Biomedical Engineering, City University of Hong Kong
- Tianrui Chang
- Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University
- Binbin Zhang
- Department of Biomedical Engineering, City University of Hong Kong
- Yuyu Gao
- Department of Biomedical Engineering, City University of Hong Kong
- Jingyou Su
- Department of Biomedical Engineering, City University of Hong Kong
- Hao Bai
- Department of Laboratory Medicine, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Liver Surgery, Department of Pathology, West China Hospital, Sichuan University
- Jie Hu
- Department of Laboratory Medicine, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Liver Surgery, Department of Pathology, West China Hospital, Sichuan University
- Chun Ki Yiu
- Department of Biomedical Engineering, City University of Hong Kong
- Chenjie Xu
- Department of Biomedical Engineering, City University of Hong Kong
- Wenchuang Hu
- Department of Laboratory Medicine, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Liver Surgery, Department of Pathology, West China Hospital, Sichuan University
- Jiandong Huang
- Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Lingqian Chang
- Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University
- Xinge Yu
- Department of Biomedical Engineering, City University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-023-43189-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Abstract The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.
