Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

Zhiyuan Niu; Qian Shi; Wenlong Zhang; Yuxin Shu; Nanfei Yang; Bing Chen; Qingsong Wang; Xuyang Zhao; Jiajia Chen; Nan Cheng; Xiujing Feng; Zichun Hua; Jianguo Ji; Pingping Shen

doi:10.1038/s41467-017-00523-6

Nature Communications (Oct 2017)

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

Zhiyuan Niu,
Qian Shi,
Wenlong Zhang,
Yuxin Shu,
Nanfei Yang,
Bing Chen,
Qingsong Wang,
Xuyang Zhao,
Jiajia Chen,
Nan Cheng,
Xiujing Feng,
Zichun Hua,
Jianguo Ji,
Pingping Shen

Affiliations

Zhiyuan Niu: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Qian Shi: Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio
Wenlong Zhang: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Yuxin Shu: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Nanfei Yang: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Bing Chen: Department of Hematology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Qingsong Wang: The State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University
Xuyang Zhao: The State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University
Jiajia Chen: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Nan Cheng: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Xiujing Feng: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Zichun Hua: State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences, Nanjing University
Jianguo Ji: The State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University
Pingping Shen: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University

DOI: https://doi.org/10.1038/s41467-017-00523-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 18

Abstract

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Tumor associated macrophages (TAMs) promote cancer progression. Here, the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of tumour growth in a transgenic mouse model of breast cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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