Nature Communications (Aug 2019)
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics
- Helen E. Speedy,
- Renée Beekman,
- Vicente Chapaprieta,
- Giulia Orlando,
- Philip J. Law,
- David Martín-García,
- Jesús Gutiérrez-Abril,
- Daniel Catovsky,
- Sílvia Beà,
- Guillem Clot,
- Montserrat Puiggròs,
- David Torrents,
- Xose S. Puente,
- James M. Allan,
- Carlos López-Otín,
- Elias Campo,
- Richard S. Houlston,
- José I. Martín-Subero
Affiliations
- Helen E. Speedy
- Division of Genetics and Epidemiology, Institute of Cancer Research
- Renée Beekman
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Vicente Chapaprieta
- Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona
- Giulia Orlando
- Division of Genetics and Epidemiology, Institute of Cancer Research
- Philip J. Law
- Division of Genetics and Epidemiology, Institute of Cancer Research
- David Martín-García
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Jesús Gutiérrez-Abril
- Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
- Daniel Catovsky
- Division of Genetics and Epidemiology, Institute of Cancer Research
- Sílvia Beà
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Guillem Clot
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Montserrat Puiggròs
- Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
- David Torrents
- Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
- Xose S. Puente
- Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
- James M. Allan
- Northern Institute for Cancer Research, Newcastle University
- Carlos López-Otín
- Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
- Elias Campo
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Richard S. Houlston
- Division of Genetics and Epidemiology, Institute of Cancer Research
- José I. Martín-Subero
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- DOI
- https://doi.org/10.1038/s41467-019-11582-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci.
