Clionaterpene, a New Cadinene Sesquiterpene from the Marine Sponge <i>Cliona</i> sp.

Abstract

Clionaterpene (1), a new cadinene sesquiterpene, along with six known compounds 2–7 were isolated from the marine sponge Cliona sp. The structure of 1 with absolute configuration was determined by the spectroscopic data (UV, IR, MS, and NMR) and quantum chemical calculation. Compound 1 was the first cadinene sesquiterpene metabolite isolated from this genus. In addition, the cytotoxic and antibacterial activities of these compounds were evaluated. However, none of them exhibited significant inhibition effects.

Keywords

• Clionidae
• marine sponge
• <i>Cliona</i>
• cadinene sesquiterpene