Susceptibilidade da mucosa gástrica à ação lesiva de um sal biliar em ratos chagásicos crônicos

Abstract

Ratos inoculados previamente com a cepa Y do Trypanosoma cruzi (n = 15) e ratos-controles de mesma idade e sexo (n = 15) foram submetidos a estudo que consistiu no exame da mucosa gástrica após a exposição in vivo da mesma à solução acidificada de um sal biliar, o taurocolato de sódio (TC). Em 10 animais de cada grupo procedeu-se também à contagem dos neurônios do plexo mientérico do estômago e ao exame histopatológico dos corpos neuronais, feito em microscopia óptica convencional. Escores indicativos da gravidade das lesões produzidas pelo TC foram significativamente maiores (P Rats inoculated with the Ystrain of Trypanosoma cruzi and control rats of the same age and sex were submitted to examination of the gastric mucosa exposed in vivo to an acidified solution of a bile salt, sodium taurocholate (TC). Neuronal counts in the myenteric plexus of the stomach were also performed for several animals in both groups. The scores indicating the severity of the lesions produced by TC were significantly higher (P 0.10) was observed between chagasic (1683.6 ± 449.7, n = 10) and control (1732.8 ± 401.1, n = 10) animals. These results indicate that in experimental chronic Chagas' disease the gastric mucosa is more sensitive to the damaging action of TC, suggesting reduction of the natural cytoprotection of the stomach. This abnormality does not appear to be due to changes in intrinsic innervation that may imply a reduction of the number of intramural neurons of the stomach.

Keywords

• Doença de Chagas
• Gastropatia chagásica
• Mucosa gástrica
• Úlcera gástrica
• Sais biliares
• Chagas' disease
• Chagasic gastropathy
• Gastric mucosa
• Gastric ulcer
• Bile salts