One-pot aminobenzylation of aldehydes with toluenes

Zhiting Wang; Zhipeng Zheng; Xinyu Xu; Jianyou Mao; Patrick J. Walsh

doi:10.1038/s41467-018-05638-y

Nature Communications (Aug 2018)

One-pot aminobenzylation of aldehydes with toluenes

Zhiting Wang,
Zhipeng Zheng,
Xinyu Xu,
Jianyou Mao,
Patrick J. Walsh

Affiliations

Zhiting Wang: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University
Zhipeng Zheng: Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania
Xinyu Xu: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University
Jianyou Mao: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University
Patrick J. Walsh: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University

DOI: https://doi.org/10.1038/s41467-018-05638-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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