A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

Riccardo Sibilano; Nicolas Gaudenzio; Marianne K. DeGorter; Laurent L. Reber; Joseph D. Hernandez; Philipp M. Starkl; Oliwia W. Zurek; Mindy Tsai; Sonja Zahner; Stephen B. Montgomery; Axel Roers; Mitchell Kronenberg; Mang Yu; Stephen J. Galli

doi:10.1038/ncomms13696

Nature Communications (Dec 2016)

A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

Riccardo Sibilano,
Nicolas Gaudenzio,
Marianne K. DeGorter,
Laurent L. Reber,
Joseph D. Hernandez,
Philipp M. Starkl,
Oliwia W. Zurek,
Mindy Tsai,
Sonja Zahner,
Stephen B. Montgomery,
Axel Roers,
Mitchell Kronenberg,
Mang Yu,
Stephen J. Galli

Affiliations

Riccardo Sibilano: Department of Pathology, Stanford University School of Medicine
Nicolas Gaudenzio: Department of Pathology, Stanford University School of Medicine
Marianne K. DeGorter: Department of Pathology, Stanford University School of Medicine
Laurent L. Reber: Department of Pathology, Stanford University School of Medicine
Joseph D. Hernandez: Department of Pathology, Stanford University School of Medicine
Philipp M. Starkl: Department of Pathology, Stanford University School of Medicine
Oliwia W. Zurek: Department of Pathology, Stanford University School of Medicine
Mindy Tsai: Department of Pathology, Stanford University School of Medicine
Sonja Zahner: Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
Stephen B. Montgomery: Department of Pathology, Stanford University School of Medicine
Axel Roers: Institute for Immunology, Technische Universität Dresden
Mitchell Kronenberg: Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
Mang Yu: Department of Pathology, Stanford University School of Medicine
Stephen J. Galli: Department of Pathology, Stanford University School of Medicine

DOI: https://doi.org/10.1038/ncomms13696
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features of asthma pathology in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal