Emerging Microbes and Infections (Jan 2017)
The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages
- Jingyuan Liu,
- Yulan Sun,
- Weifeng Shi,
- Shuguang Tan,
- Yang Pan,
- Shujuan Cui,
- Qingchao Zhang,
- Xiangfeng Dou,
- Yanning Lv,
- Xinyu Li,
- Xitai Li,
- Lijuan Chen,
- Chuansong Quan,
- Qianli Wang,
- Yingze Zhao,
- Qiang lv,
- Wenhao Hua,
- Hui Zeng,
- Zhihai Chen,
- Haofeng Xiong,
- Chengyu Jiang,
- Xinghuo Pang,
- Fujie Zhang,
- Mifang Liang,
- Guizhen Wu,
- George F Gao,
- William J Liu,
- Ang Li,
- Quanyi Wang
Affiliations
- Jingyuan Liu
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Yulan Sun
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Weifeng Shi
- Institute of Pathogen BiologyTaishan Medical College, Taian 271000, China
- Shuguang Tan
- Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences, Beijing 100101, China
- Yang Pan
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Shujuan Cui
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Qingchao Zhang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences, Beijing 100005, China
- Xiangfeng Dou
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Yanning Lv
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Xinyu Li
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Xitai Li
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Lijuan Chen
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Chuansong Quan
- National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, China
- Qianli Wang
- Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences, Beijing 100101, China
- Yingze Zhao
- National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, China
- Qiang lv
- Institute of Pathogen BiologyTaishan Medical College, Taian 271000, China
- Wenhao Hua
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Hui Zeng
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Zhihai Chen
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Haofeng Xiong
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Chengyu Jiang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences, Beijing 100005, China
- Xinghuo Pang
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- Fujie Zhang
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Mifang Liang
- National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, China
- Guizhen Wu
- National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, China
- George F Gao
- Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences, Beijing 100101, China
- William J Liu
- National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, China
- Ang Li
- Beijing Ditan HospitalCapital Medical University, Beijing 100015, China
- Quanyi Wang
- Institute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, China
- DOI
- https://doi.org/10.1038/emi.2016.136
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 7
Abstract
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.Emerging Microbes & Infections (2017) 6, e4; doi:10.1038/emi.2016.136; published online 18 January 2017
Keywords
