Therapeutics and Clinical Risk Management (Aug 2022)

The Association Between Circulating Sex Hormones and Central Serous Chorioretinopathy: A Case-Control Study

  • Zhao C,
  • Huang Y,
  • Chen L,
  • Ye S,
  • Liu XQ

Journal volume & issue
Vol. Volume 18
pp. 855 – 865

Abstract

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Chun Zhao1 *, Yan Huang2 *, Lei Chen,1 Sheng Ye,1 Xiao-Qiang Liu1 𪇞partment of Ophthalmology, Tenth People’s Hospital Affiliated to Shanghai Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 2Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China* These authors contributed equally to this workCorrespondence: Xiao-Qiang Liu, Email [email protected]: Central serous chorioretinopathy (CSC) is preferential cocurated in males, however the associations between sex hormones and CSC incidence or progression remains unclear. The sex hormone concentration assessments in CSC cases and healthy controls will update the knowledge in CSC management.Methods: This case-control study included 59 CSC cases and 30 healthy controls, from January 2019 to December 2020. The CSC cases would be defined as spontaneous resolved if the subretinal fluid were absorbed within three months. The concentrations of total testosterone (TT), free testosterone (FT), estradiol (E2), sex hormone-binding globulin (SHBG), progesterone, leuteinizing hormone (LH) and dehydroepiandrosterone sulfate (DHEA-S) were detected in all the participants. The relationships between sex hormone concentrations and CSC-related characteristics were analyzed with Pearson correlation analyses.Results: Significantly increased TT, FT, FT/E2 ratio, SHBG concentrations as well as decreased DHEA-S level were detected in non-resolved CSC group compared with the control group. Comparing with the resolved ones, it was found that TT, FT and SHBG concentrations were increased in the non-resolved CSC. A significant positive correlation between TT concentrations and CMT (R2=0.168, P=0.031) as well as SRF height (R2=0.146, P=0.045) were detected in the non-solved CSC group.Conclusion: Different concentrations of TT, FT, FT/E2 ratio, DHEA-S and SHBG were detected in resolved and non-resolved CSC cases. Sex hormones were related to CSC symptom durations and related parameters.Keywords: central serous chorioretinopathy, sex hormones, cortisol, testosterone, case-control study

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