Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

Amalia Hadjitheodorou; George R. R. Bell; Felix Ellett; Shashank Shastry; Daniel Irimia; Sean R. Collins; Julie A. Theriot

doi:10.1038/s41467-021-26622-z

Nature Communications (Nov 2021)

Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

Amalia Hadjitheodorou,
George R. R. Bell,
Felix Ellett,
Shashank Shastry,
Daniel Irimia,
Sean R. Collins,
Julie A. Theriot

Affiliations

Amalia Hadjitheodorou: Department of Bioengineering, Stanford University
George R. R. Bell: Department of Microbiology and Molecular Genetics, University of California, Davis
Felix Ellett: Department of Surgery, BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School
Shashank Shastry: Department of Microbiology and Molecular Genetics, University of California, Davis
Daniel Irimia: Department of Surgery, BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School
Sean R. Collins: Department of Microbiology and Molecular Genetics, University of California, Davis
Julie A. Theriot: Department of Biology and Howard Hughes Medical Institute, University of Washington

DOI: https://doi.org/10.1038/s41467-021-26622-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing transmission of receptor inputs at the cell rear.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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