Nature Communications (Nov 2022)

Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

  • Louisa E. Linders,
  • Lefkothea Patrikiou,
  • Mariano Soiza-Reilly,
  • Evelien H. S. Schut,
  • Bram F. van Schaffelaar,
  • Leonard Böger,
  • Inge G. Wolterink-Donselaar,
  • Mieneke C. M. Luijendijk,
  • Roger A. H. Adan,
  • Frank J. Meye

DOI
https://doi.org/10.1038/s41467-022-34625-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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Stress can increase the consumption of rewarding food, which contributes to obesity and binge eating disorders. Here the authors show that stress eating depends on a strengthened connection between the lateral hypothalamus and the dopamine system.