Nature Communications (Oct 2017)
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy
- Ingo Marenholz,
- Sarah Grosche,
- Birgit Kalb,
- Franz Rüschendorf,
- Katharina Blümchen,
- Rupert Schlags,
- Neda Harandi,
- Mareike Price,
- Gesine Hansen,
- Jürgen Seidenberg,
- Holger Röblitz,
- Songül Yürek,
- Sebastian Tschirner,
- Xiumei Hong,
- Xiaobin Wang,
- Georg Homuth,
- Carsten O. Schmidt,
- Markus M. Nöthen,
- Norbert Hübner,
- Bodo Niggemann,
- Kirsten Beyer,
- Young-Ae Lee
Affiliations
- Ingo Marenholz
- Max-Delbrück-Center (MDC) for Molecular Medicine
- Sarah Grosche
- Max-Delbrück-Center (MDC) for Molecular Medicine
- Birgit Kalb
- Max-Delbrück-Center (MDC) for Molecular Medicine
- Franz Rüschendorf
- Max-Delbrück-Center (MDC) for Molecular Medicine
- Katharina Blümchen
- Department of Allergy, Pulmonology and Cystic Fibrosis, Children’s Hospital, Goethe University
- Rupert Schlags
- Department of Pediatric Pneumology and Allergology, Wangen Hospital
- Neda Harandi
- Department of Pediatric Pneumology and Allergology, Wangen Hospital
- Mareike Price
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School
- Gesine Hansen
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School
- Jürgen Seidenberg
- Department of Pediatric Pneumology and Allergology, Neonatology and Intensive Care, Medical Campus of University Oldenburg
- Holger Röblitz
- Department of Pediatrics and Adolescent Medicine, Sana Klinikum Lichtenberg
- Songül Yürek
- Department of Pediatric Pneumology and Immunology, Charité University Medical Center
- Sebastian Tschirner
- Department of Pediatric Pneumology and Immunology, Charité University Medical Center
- Xiumei Hong
- Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health
- Xiaobin Wang
- Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health
- Georg Homuth
- Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald
- Carsten O. Schmidt
- Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald
- Markus M. Nöthen
- Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn
- Norbert Hübner
- Max-Delbrück-Center (MDC) for Molecular Medicine
- Bodo Niggemann
- Department of Pediatric Pneumology and Immunology, Charité University Medical Center
- Kirsten Beyer
- Department of Pediatric Pneumology and Immunology, Charité University Medical Center
- Young-Ae Lee
- Max-Delbrück-Center (MDC) for Molecular Medicine
- DOI
- https://doi.org/10.1038/s41467-017-01220-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Food allergy is an increasing public health problem. In a genome-wide scan of children diagnosed by oral food challenge, Marenholz et al. find new genetic associations underlying food allergy, implicating the immune system and the epithelial barrier.
