Nature Communications (Sep 2021)

Generalized and scalable trajectory inference in single-cell omics data with VIA

  • Shobana V. Stassen,
  • Gwinky G. K. Yip,
  • Kenneth K. Y. Wong,
  • Joshua W. K. Ho,
  • Kevin K. Tsia

DOI
https://doi.org/10.1038/s41467-021-25773-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Scalable trajectory inference for multi-omic single cell datasets is challenging in terms of capturing non-tree complex topologies. Here the authors present a method, VIA, that scales to millions of cells across multiple omic modalities using lazy-teleporting random walks.