THE ANTIOXIDANT EFFECTS OF CAPPARIS OVATA AND DEFERASIROX IN PATIENTS WITH THALASSEMIA MAJOR

Abstract

Iron overload and auto-oxidation of unpaired globin chains are the main causes of oxidative stress in patients with thalassemia major. In the present study, we aimed to investigate the antioxidant effects of capparis ovatta and deferasirox in thalassemic patients. A total 40 patients with thalassemia major aged between 7-30 years, who have been taken regular red cell transfusion and chelation (Deferasirox:30 mg/kg/day) for one year are involved. They were divided into two groups as control and study group randomly. Both study and control groups were followed by regular transfusion and chelation therapy. In addition study group have been taken the marmalade of dried capparis ovata the breakfast with a daily dose of 12.5 gr younger than 10 years and 25 gr older than 10 years for 6 months. Hematological, biochemical parameters, ferritin at every month and antioxidant enzymes (MDA, CAT, GPX, SOD) were measured at the beginning and at the end of the study. There was a significant difference between initial and final parameters of the MDA levels in study group. SOD levels also decreased statistically in both of the groups, CAT and GPX levels didn’t decrease significantly in both of the groups. Ferritin levels declined significiantly both in control and study group. As conclusion, our findings suggest that combination of capparis ovata with deferasirox may have additive effect on decreasing the oxidative damage and hepatoxicity. This is preliminary work, it needs further works.

Keywords

• Original articles