Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis

Hao Li; Meng Wang; Biao Huang; Su-Wen Zhu; Jun-Jie Zhou; De-Run Chen; Ran Cui; Mingxi Zhang; Zhi-Jun Sun

doi:10.1038/s41467-021-27485-0

Nature Communications (Dec 2021)

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis

Hao Li,
Meng Wang,
Biao Huang,
Su-Wen Zhu,
Jun-Jie Zhou,
De-Run Chen,
Ran Cui,
Mingxi Zhang,
Zhi-Jun Sun

Affiliations

Hao Li: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University
Meng Wang: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology
Biao Huang: College of Chemistry and Molecular Sciences, Wuhan University
Su-Wen Zhu: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University
Jun-Jie Zhou: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University
De-Run Chen: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University
Ran Cui: College of Chemistry and Molecular Sciences, Wuhan University
Mingxi Zhang: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology
Zhi-Jun Sun: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University

DOI: https://doi.org/10.1038/s41467-021-27485-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Hypoxia and immunosuppression contribute to tumor resistance to radiotherapy (RT). Here the authors design a nanoprobe based on NIR-IIb emitting quantum dots for image-guided RT and modified with catalase to relieve hypoxia in the tumor microenvironment, enhancing the precision and efficacy of RT and promoting anti-tumor immune responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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