Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila

Valentina Botero; Bethany A. Stanhope; Elizabeth B. Brown; Eliza C. Grenci; Tamara Boto; Scarlet J. Park; Lanikea B. King; Keith R. Murphy; Kenneth J. Colodner; James A. Walker; Alex C. Keene; William W. Ja; Seth M. Tomchik

doi:10.1038/s41467-021-24505-x

Nature Communications (Jul 2021)

Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila

Valentina Botero,
Bethany A. Stanhope,
Elizabeth B. Brown,
Eliza C. Grenci,
Tamara Boto,
Scarlet J. Park,
Lanikea B. King,
Keith R. Murphy,
Kenneth J. Colodner,
James A. Walker,
Alex C. Keene,
William W. Ja,
Seth M. Tomchik

Affiliations

Valentina Botero: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Bethany A. Stanhope: Department of Biological Sciences, Florida Atlantic University
Elizabeth B. Brown: Department of Biological Sciences, Florida Atlantic University
Eliza C. Grenci: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Tamara Boto: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Scarlet J. Park: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Lanikea B. King: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Keith R. Murphy: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Kenneth J. Colodner: Program in Neuroscience and Behavior, Mount Holyoke College
James A. Walker: Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School
Alex C. Keene: Department of Biological Sciences, Florida Atlantic University
William W. Ja: Department of Neuroscience, The Scripps Research Institute, Scripps Florida
Seth M. Tomchik: Department of Neuroscience, The Scripps Research Institute, Scripps Florida

DOI: https://doi.org/10.1038/s41467-021-24505-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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