Nature Communications (Jun 2016)
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
- Xiangdong Zheng,
- Anand Ramani,
- Komal Soni,
- Marco Gottardo,
- Shuangping Zheng,
- Li Ming Gooi,
- Wenjing Li,
- Shan Feng,
- Aruljothi Mariappan,
- Arpit Wason,
- Per Widlund,
- Andrei Pozniakovsky,
- Ina Poser,
- Haiteng Deng,
- Guangshuo Ou,
- Maria Riparbelli,
- Callaini Giuliano,
- Anthony A. Hyman,
- Michael Sattler,
- Jay Gopalakrishnan,
- Haitao Li
Affiliations
- Xiangdong Zheng
- Department of Basic Medical Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University
- Anand Ramani
- Institute for Biochemistry I and Center for Molecular Medicine of the University of Cologne
- Komal Soni
- Institute of Structural Biology, Helmholtz Zentrum München
- Marco Gottardo
- Department of Life Sciences, University of Siena
- Shuangping Zheng
- Department of Basic Medical Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University
- Li Ming Gooi
- Institute for Biochemistry I and Center for Molecular Medicine of the University of Cologne
- Wenjing Li
- MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University
- Shan Feng
- MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University
- Aruljothi Mariappan
- Institute for Biochemistry I and Center for Molecular Medicine of the University of Cologne
- Arpit Wason
- Institute for Biochemistry I and Center for Molecular Medicine of the University of Cologne
- Per Widlund
- Max Planck Institute of Molecular Cell Biology and Genetics
- Andrei Pozniakovsky
- Max Planck Institute of Molecular Cell Biology and Genetics
- Ina Poser
- Max Planck Institute of Molecular Cell Biology and Genetics
- Haiteng Deng
- MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University
- Guangshuo Ou
- MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University
- Maria Riparbelli
- Department of Life Sciences, University of Siena
- Callaini Giuliano
- Department of Life Sciences, University of Siena
- Anthony A. Hyman
- Max Planck Institute of Molecular Cell Biology and Genetics
- Michael Sattler
- Institute of Structural Biology, Helmholtz Zentrum München
- Jay Gopalakrishnan
- Institute for Biochemistry I and Center for Molecular Medicine of the University of Cologne
- Haitao Li
- Department of Basic Medical Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University
- DOI
- https://doi.org/10.1038/ncomms11874
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control.
